Mimetics of Hormetic Agents: Stress-Resistance Triggers
نویسندگان
چکیده
منابع مشابه
Mimetics of hormetic agents: stress-resistance triggers.
Mimetics of hormetic agents offer a novel approach to adjust dose to minimize the risk of toxic response, and maximize the benefit of induction of at least partial physiological conditioning. Nature selected and preserved those organisms and triggers that promote tolerance to stress. The induced tolerance can serve to resist that challenge and can repair previous age, disease, and trauma damage...
متن کاملNutrition, hormetic stress and health.
Hormesis defines an effect where exposure to a low dose of a toxic agent results in a beneficial response. It has been described in organisms exposed to low-dose radiation, heat stress, and chemicals. The effect is characterised by a J-shaped dose-response as opposed to a linear dose-response. Confirmation of the general phenomena of hormesis has proved difficult due to the lack of appropriate ...
متن کاملAlternative Strategy for Alzheimer's Disease: Stress Response Triggers
Stress resistance capacity is a hallmark of longevity protection and survival throughout the plant and animal kingdoms. Latent pathway activation of protective cascades, triggered by environmental challenges to tolerate heat, oxygen deprivation, reactive oxygen species (ROS), diet restriction, and exercise provides tolerance to these stresses. Age-related changes and disease vulnerability mark ...
متن کاملHyperosmotic stress enhances cytotoxicity of SMAC mimetics
Inhibitors of apoptosis (IAP) proteins contribute to cell death resistance in malignancies and emerged as promising targets in cancer therapy. Currently, small molecules mimicking the IAP-antagonizing activity of endogenous second mitochondria-derived activator of caspases (SMAC) are evaluated in phase 1/2 clinical trials. In cancer cells, SMAC mimetic (SM)-mediated IAP depletion induces tumor ...
متن کاملHormetic Responses of Lonicera Japonica Thunb. To Cadmium Stress
The hormetic responses of Lonicera japonica Thunb. to cadmium (Cd) stress were investigated in a hydroponic experiment. The present results showed that root length and total biomass dry weight increased in comparison with the control at low concentrations Cd. The height of the plant exposed to 2.5 and 5 mg L(-1) Cd increased significantly by 11.9% and 12.8% relative to the control, and with the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Dose-Response
سال: 2010
ISSN: 1559-3258,1559-3258
DOI: 10.2203/dose-response.09-025.sonneborn